WebNon-canonical chimeric RNAs are widely detected in normal physiology, although several have been shown to have a cancer-specific expression pattern. Further studies have indicated that some of them play fundamental roles in controlling cell growth and motility, and may have functions independent of the parental genes. WebMay 27, 2024 · Non-canonical chimeric RNAs are widely detected in normal physiology, although several have been shown to have a cancer-specific expression pattern. Further …
Understanding the Role of Epigenetics in Cancer
WebJul 4, 2024 · Chimeric RNAs are demonstrated to be not the elusive features of cancer cells, but also present in normal physiology and with diverse functions. Genomic technology is advancing rapidly; whole … WebChimeric RNAs, or fusion transcripts, are RNA transcripts composed of RNA fragments encoded by two separate genes. Chimeric RNAs have been known to be the products of gene fusions created via chromosomal rearrangement, and are often considered ideal biomarkers/drug targets for cancer [1–7]. hill\u0027s prescription canned dog food
Chimeric RNAs in Cancer and Normal Physiology
WebAug 11, 2014 · Reports have demonstrated that at least some of these chimeric RNAs are generated via intergenic splicing. In this review, ... We discuss the implications of the chimeric RNAs in both cancer and normal physiology, as some of these fusion transcripts are found in normal, noncancerous cells with sequences identical to those … WebJul 30, 2024 · Chimeric RNAs are transcripts that are generated by gene fusion and intergenic splicing events, thus comprising nucleotide sequences from different parental genes. In the past, Northern blot analysis and RT-PCR were used to detect chimeric RNAs. However, they are low-throughput and can be [...] Read more. WebChimeric fusion RNAs can be gener-ated by intergenic splicing, including trans-splicing andcis-splicingbetween genes. Fusion RNAs (and proteins) are tradi-tionally viewed as specific to cancer, they are also present in normal physiology. Intergenically spliced fusion RNAs can complicate the application of fusion RNAs in cancer detection and ... smart campus stin