Circhipk2
WebCircHIPK2 has been found remarkably upregulated in nasopharyngeal carcinoma (NPC) tissues . In vitro and in vivo studies in animal models showed that circHIPK2 promotes proliferation of NPC cells while knockdown of circHIPK2 dampens the growth of NPC cells . Mechanistically, circHIPK2 downregulated HIPK2 at the protein levels and consequently ... WebIn contrast, patients with high circHIPK2 expression had lower overall survival rate and disease-free survival rate than those with low circHIPK2 expression. circHIPK2 expression in normal intestinal epithelial cells was lower than that in CRC cell lines. circHIPK2 promoted CRC progression. miR-485-5p reduced CRC progression. miR-485-5p, as the ...
Circhipk2
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WebIn this article of EBioMedicine, Guangtian Wang et al. describe the effects of the circular RNA homeodomain-interacting protein kinase 2 (circHIPK2) on neural stem cells (NSC) and on neurons generated from NSC, both in vitro and in a mouse model of focal cerebral ischemia .. After their initial description in the 1970s, our understanding of circular RNAs … Web(d-e) Western blot analysis showing GFAP and TUJ1 protein expression in the circCon-NSC group and in the circHIPK2-NSC group. All data were presented as mean § SEM of 3 independent experiments.
WebIt has long been known that tissue non-specific alkaline phosphatase (TNAP) is essential for the correct formation of bone, as altered expression or function of this enzyme results in hypophosphatasia, a disease characterised by compromised bone structure, density and strength. However, recent evidence strongly suggests that the enzyme also has a role in … WebAug 8, 2024 · (B) circHIPK2 siRNA lentivirus injection successfully decreased circHIPK2 expression, as determined by real-time PCR. Two wk after microinjection, the mice were killed, and circHIPK2 expression was measured. N = 6 animals/group. *P<0.05 vs. the circ siRNA control group by the Student t test.
WebMay 8, 2024 · A pLC5-circHipk2-Flag vector and pLC5-circHipk2vector were constructed by Geenseed Biotech (Guangzhou, China). Cellular lysates from C2C12 myoblasts with a transfecting pLC5-circHipk2-Flag vector or pLC5-circHipk2 were divided into an input group and pull-down group, in which the pull-down group was used for circHipk2 pull … WebApr 1, 2024 · CircHIPK2 promoted astrocytic inflammation. (A) Representative blots showed the expression of iNOS and GFAP in primary astrocytes with LPS treatment at various …
WebResults circHIPK2 (hsa-circ-0001756) is considerably upregulated in NPC. Differentially expressed circRNAs were explored via RNA sequencing data in four NPC along with normal nasopharyngeal tissues to determine their significance in the onset and progress of the disease (unpublished data) ().The results showed elevated contents of circRNAs were …
WebMay 1, 2024 · Request PDF On May 1, 2024, Yuyu Xu and others published Sa1115 – The Potential Function of Circular Rna Circhipk2 in Infection-Associated Colitis and Colorectal Cancer Find, read and cite ... imax theater bay areaimax theater brooklynWebZestimate® Home Value: $311,500. 1252 Chinook Cir, Clarksville, TN is a single family home that contains 1,910 sq ft and was built in 2010. It contains 3 bedrooms and 2.5 … list of icons flutterWebOct 15, 2024 · CircHIPK2 in tumor tissue samples (DDP-sensitive and DDP-resistant) and normal tissues was detected for the first time. The outcomes displayed that circHIPK2 was upregulated in tumor tissues, particularly in DDP-resistant tissues (Fig. 1A).Subsequently, a significant increase in IC50 values in the two drug-resistant strains (A549/DDP and … imax theater browardWebJan 15, 2024 · CircHIPK2 increased SIGMAR1 expression by suppressing miR-124-2HG activity . In bladder cancer, circHIPK3 affected the expression of heparanase by competitively binding to miR-558 [ 23 ]; circRNA MYLK and lncRNA H19 increase the expression of DNMT3, VEGFA, and ITGB1 by suppressing miR-29a-3P activity [ 24 ]. list of icse schools in navi mumbaiWebApr 5, 2024 · Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. Rongrong Huang, Liangliang Cai, Xiaofei Ma, Kai Shen. Circular RNAs (circRNAs) are a subclass of noncoding RNAs and widely involve in the occurrence of multiple human diseases. It is an urgent task to clarify circRNA … list of icse schools in keralaWebView 1 photos for 1252 Chinook Cir, Clarksville, TN 37042, a 3 bed, 3 bath, 1,910 Sq. Ft. single family home built in 2010 that was last sold on 05/04/2011. imax theater cary nc