Immunometabolism in the single-cell era

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August undefined, 2024

Witryna19 lut 2024 · Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4 + regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their respective draining lymph nodes (LNs) and spleen. In these tissues, … Witryna30 wrz 2024 · → I am an accomplished researcher equipped with specialist expertise in metabolic disease and host-pathogen interactions, gained throughout my PhD and postdoctoral training. → As demonstrated by my publication record, I have a deep knowledge of tissue engineering, epigenetics, metabolism, immunity, and single …

Immunometabolism in the Single-Cell Era - PubMed

WitrynaArtyomov, M. N., & Van den Bossche, J. (2024). Immunometabolism in the Single-Cell Era. Cell Metabolism. doi:10.1016/j.cmet.2024.09.013 flag with green triangle

Analyzing macrophage metabolism with Met-Flow - Abcam

Witryna15 kwi 2024 · Artyomov, M. N. & van den Bossche, J. Immunometabolism in the single-cell era. Cell Metab. 32 , 710–725 (2024). Article CAS PubMed PubMed Central … Witryna3 lis 2024 · Immunometabolism in the Single-Cell Era. Maxim N. Artyomov, Jan Van den Bossche. Pages 710-725 View PDF. Article preview. Clinical and Translational … Witryna31 mar 2024 · Recent research about immunometabolism has contributed to the realization that stimuli and changes in the environment macrophages and DCs are exposed to, eventually converge into alterations in their metabolic properties. ... However, recent advances in single-cell technologies, such single-cell RNA sequencing and … flag with green stripe

Immunometabolism the CyTOF way - ScienceDirect

Immunometabolism: From basic mechanisms to translation

Witryna13 kwi 2024 · In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8 + T cells metabolic changes at the single-cell level. This approach identified a transition state early in T cell activation that is characterized by high glycolytic and oxidative activity, providing new insight into the metabolic changes that underlie … WitrynaImmunometabolism in the Single-Cell Era Artyomov, M. N. & Van den Bossche, J., 3 Nov 2024, In: Cell metabolism. 32, 5, p. 710-725 16 p. Research output: Contribution … flag with green triangle on leftWitryna7 lut 2024 · Summary. During immune challenge, T lymphocytes engage pathways of anabolic metabolism to support clonal expansion and the development of effector functions. Here we report a critical role for the non-essential amino acid serine in effector T cell responses. Upon activation, T cells upregulate enzymes of the serine, glycine, … flag with green white and red vertical bars

"WitrynaAdvances in high-dimensional single-cell analyses and metabolic flux have improved our understanding of immunometabolism and brought the potential to identify new therapeutic strategies for cancer (Artyomov and den Bossche, 2024; Zhou et al., 2024). How best to translate these findings remains an open question, especially given the … " - Immunometabolism in the single-cell era

Immunometabolism in the single-cell era

WitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these … Witryna15 kwi 2024 · Artyomov, M. N. & van den Bossche, J. Immunometabolism in the single-cell era. Cell Metab. 32 , 710–725 (2024). Article CAS PubMed PubMed Central Google Scholar

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Witryna28 mar 2024 · Verberk et al. describe accessible, stepwise workflows for profiling mouse and human macrophage immunometabolism. Their toolbox integrates distinct metabolic and functional immune assays utilizing a 96-well plate format, providing a practical, semi-high-throughput approach to assess cellular metabolism of immune cells. Witryna13 kwi 2024 · In the past few years, several studies have demonstrated that cellular metabolic function is drastically altered in OA and aberrant immunometabolism may be a key feature of many phenotypes of OA 7.

Witryna13 kwi 2024 · Immunometabolism the CyTOF way. In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8 + T cells metabolic changes at the single-cell level. This approach identified a transition state early in T cell activation that is characterized by high glycolytic and oxidative activity, providing new insight into ... Witryna13 kwi 2024 · Immunometabolism the CyTOF way. In this issue of Immunity, Levine et al. report a CyTOF-based approach for the analyses of CD8 + T cells metabolic …

Witryna27 wrz 2024 · Metabolism as a driver of immunity. Immune cell activation initiates a programme of cell growth and differentiation, often coupled to proliferation. By the 1970s it was known that lymphocytes ... WitrynaLiczba wierszy: 23 · Single-cell metabolomics is currently too premature for large-scale applications, and thus ...

WitrynaLiczba wierszy: 23 · 6 paź 2024 · Abstract. Emerging research has identified metabolic pathways that are crucial for the proper ...

WitrynaMaternal obesity is associated with phenotypic alterations in fetal immune cells by single-cell mass cytometry. Am. J. Reprod. Immunol. 2024; ... The influence of a high-fat dietary environment in the fetal period on postnatal metabolic and immune function. Obesity. 2010; ... Immunometabolism. 2024; 4 e220008 https: ... canon print shop proWitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these single-cell techniques and their ability to validate common principles in immunometabolism, while also revealing context-dependent metabolic … flag with green white and light blueWitryna29 wrz 2024 · This review highlights the leading techniques used to study immunometabolism and their development, the immune cells at the maternal-fetal … canon print service windows 11WitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these … flag with green white and red stripesWitrynaBut with the emergence of single-cell applications, researchers can now estimate the metabolic state of individual immune cells in clinical samples. Here, we review these single-cell techniques and their ability to validate common principles in immunometabolism, while also revealing context-dependent metabolic … canon print service app for laptopWitryna2 sie 2011 · Bioresource Collection and Research (BCRC) provided this video to introduce the protocol of MTT assay. MTT assay allows assessing the viability and the proliferation of cells. This is a colorimetric assay that measures the reduction of yellow 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) by mitochondrial … flag with green white and blueWitryna4 lut 2024 · Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics. Adv Immunol. 2024;141:1–31. Article CAS PubMed Google Scholar canon print shop pro plugin