WebbCD47 is a cell surface receptor over expressed on cancer cells that acts as a “don’t eat me” signal and inhibits the engulfment of cancer cells by phagocytes. This study explores the role of a novel monoclonal antibody, Hu5F9-G4, that blocks CD47’s interaction with its ligand SIRPα, in the phagocytosis of pancreatic cancer cells. Webb16 nov. 2016 · The CD47 protein acts as a “don’t eat me” signal to immune cells called macrophages, which normally engulf and devour cancer cells and other diseased and dying cells. It turns out that nearly every kind of …
Anti-GD2 synergizes with CD47 blockade to mediate tumor
Webb31 juli 2024 · "Finding that not all patients responded to anti-CD47 antibodies helped fuel our research at Stanford to test whether non-responder cells and patients might have alternative 'don't eat me' signals ... Webb8 mars 2024 · Forscher:innen finden Hebel im Kampf gegen „Covid-Lungenfibrose“ – Verabreichung von Covid-Medikament Lagevrio eingestellt – Nächste Corona-Influenza-Wellen: Erster Kombitest in den USA – Prognose rechnet mit Rückgang bei Spitalspatienten – WHO verlangt US-Daten zu Corona-„Labortheorie“ – Bulgarien entsorgt Großmengen … scratch to the cornea
CD47-blocking therapies stimulate macrophage cytokine secretion …
WebbStanford Libraries' official online search tool for books, media, journals, databases, government documents and more. Modulation of CD47-SIRPα innate immune … Webb2 mars 2024 · Forty Seven’s lead program, magrolimab, is a monoclonal antibody against the CD47 receptor, a “don’t eat me” signal that cancer cells commandeer to avoid being ingested by macrophages. This antibody is currently being evaluated in multiple clinical studies in patients with myelodysplastic syndrome, acute myeloid leukemia, non … Webb24 apr. 2012 · Antibodies against CD47, which block tumor cell CD47 interactions with macrophage signal regulatory protein-α, have been shown to decrease tumor size in … scratch to python converter online